Investigation of transcription factors involved in therapy resistance in acute myeloid leukemias

Organisation/Company Università di Torino Research Field Medical sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 9 Jun 2026 - 13:00 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Therapy resistance is mediated by many factors, including cellular plasticity driven by transcription factors. The project involves the identification and study of transcription factors that may mediate resistance to therapies in acute myeloid leukemias, with a focus on the novel BCL-2 inhibitor venetoclax. The project will involve the use of molecular techniques (RT-PCR, immunofluorescence, western blot, ChIP) and cellular approaches (viability assays, use of inhibitors) to investigate the involvement of these factors in the cellular response to therapy and to identify molecular mechanisms activated by tumor cells to resist such treatments.

Mandatory requirement for admission to the selection: italian Laurea Magistrale, or Laurea a Ciclo Unico, or an equivalent degree from foreign Universities, obtained no more than 6 years prior to the application deadline (i.e obtained after 09/06/2020).

• Italy

Eligibility of fellows: country/ies of residence:

• All

Eligibility of fellows: nationality/ies: