Ref. 406 - Development of 3D cell biology techniques, live microscopy and biochemical technique[...]
Descrizione dell'offerta
Overview
Organisation/Company Alma Mater Studiorum - Universita' di Bologna Department DIBINEM - DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE Research Field Medical sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 27 Feb 2026 - 12:00 (UTC) Country Italy Type of Contract Temporary Job Status Other Offer Starting Date 1 Jan 1970 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Responsibilities
- To develop innovative technologies for precision medicine in orthopedic diseases through advanced cell biology techniques, 3D cellular models (spheroids, organoids, tissue cultures), and patient-derived cells (primary cultures, induced pluripotent stem cells).
- Integrate dynamic chip-based models to reconstruct the vascular–tumor interface and complex tumor microenvironments, enabling the analysis of biological processes under controlled in-vitro conditions.
- Apply advanced morphological techniques (multiphoton confocal microscopy, live holotomography), molecular biology methods (real-time PCR, Western blotting), and analyses of metabolic pathways related to cellular stress, including the unfolded protein response.
- Aim to create translational models for pharmacological screening and personalized assays, with a focus on orthopedic diseases of high incidence or severity (neoplasms, osteoarthritis, osteoporosis), while reducing the use of animal models.